Spirolast Tablet

Introduction

Spirolast is a prescription medication that contains the active ingredient Roflumilast. It is available under the brand name Spirolast. This medication is primarily used for the treatment of a specific type of chronic obstructive pulmonary disease (COPD) known as severe COPD with chronic bronchitis and a history of exacerbations.

Uses

Spirolast is prescribed to manage symptoms and reduce the risk of exacerbations in patients with severe COPD and chronic bronchitis. It is not intended for the treatment of asthma or other respiratory conditions. This medication works by reducing inflammation and improving lung function, which can help alleviate symptoms such as coughing, shortness of breath, and wheezing.

Dosage and Administration

follow your healthcare provider’s instructions regarding the dosage and administration of Spirolast. Typically, the recommended dosage is one tablet (500 mcg) taken orally once daily, preferably in the morning. The tablet should be swallowed whole with water and can be taken with or without food. Do not crush, chew, or break the tablet unless advised by your doctor.

Mechanism of Action

The active ingredient in Spirolast, Roflumilast, belongs to a class of medications called phosphodiesterase-4 (PDE-4) inhibitors. It works by inhibiting the enzyme PDE-4, which is involved in the inflammation process in the lungs. By reducing inflammation, Spirolast helps to improve lung function and decrease the frequency of exacerbations in patients with severe COPD.

Side Effects

Common side effects may include diarrhea, nausea, headache, and back pain. These side effects are usually mild and temporary. However, if they persist or worsen, notify your doctor.

Serious side effects are rare but may include signs of allergic reaction (such as rash, itching, swelling, severe dizziness, or difficulty breathing), mood changes, depression, or suicidal thoughts. If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Spirolast may interact with certain medications, including strong CYP3A4 inhibitors (such as ketoconazole, clarithromycin, or ritonavir) and strong CYP3A4 inducers (such as rifampin or carbamazepine). These interactions can affect the metabolism and effectiveness of Spirolast. Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal products, before starting Spirolast.

Precautions

Before taking Spirolast, inform your doctor about any medical conditions you have, especially liver problems, history of depression or suicidal thoughts, or any allergies. This medication may not be suitable for everyone, and your doctor will evaluate the potential risks and benefits for your specific situation.

Spirolast is not recommended for use in pregnant or breastfeeding women. Avoid alcohol while taking this medication, as it may increase the risk of side effects.

Storage

Spirolast should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use Spirolast after the expiration date printed on the packaging.

Patient Tips

• Take Spirolast exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• It may take several weeks of regular use for Spirolast to start working effectively. Be patient and continue taking the medication as directed.
• If you experience any new or worsening symptoms while taking Spirolast, such as increased cough, difficulty breathing, or chest pain, contact your doctor immediately.
• Attend all scheduled follow-up appointments with your healthcare provider to monitor your progress and discuss any concerns or questions you may have.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• DAXAS 250 micrograms tablets (Health Professionals SmPC) Available at:
• Roflumilast (Drugs.com) [Accessed 8 Jun. 2024] (online) Available at:
• roflumilast 0.3 % topical cream (RX) [Accessed 13 Jun. 2024] (online) Available at:
• Roflumilast (MedlinePlus) [Accessed 23 Jun. 2024] (online) Available at:
• Drakos A, Vender R, Torres T. Topical roflumilast for the treatment of psoriasis. Expert Rev Clin Immunol. 2023 Jul-Dec;19(9):1053-1062. doi: 10.1080/1744666X.2023.2219897. Epub 2023 May 30. [Accessed 21 Jun. 2024] Available at: