Tazobax TB 1000mg/120mg Injection

Introduction

Tazobax TB is a prescription medication that contains two active ingredients: Ceftazidime and Tobramycin. Ceftazidime is a third-generation cephalosporin antibiotic, while Tobramycin is an aminoglycoside antibiotic. This combination medication is primarily used to treat bacterial infections in patients who require both antibiotics to effectively combat the infection.

Uses

Tazobax TB is prescribed to treat a variety of bacterial infections caused by susceptible organisms. It is commonly used in cases of lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, and intra-abdominal infections. The medication is effective against a wide range of bacteria, including both gram-positive and gram-negative organisms.

Dosage and Administration

The dosage of Tazobax TB may vary depending on the specific infection being treated, the patient’s age, weight, and renal function. It is usually administered intravenously, either as a slow infusion or as a bolus injection, under the supervision of a healthcare professional. The exact dose and duration of treatment should be determined by the prescribing physician.

Mechanism of Action

Ceftazidime works by inhibiting the synthesis of bacterial cell walls, thereby preventing the growth and reproduction of the bacteria. Tobramycin, on the other hand, disrupts the bacterial protein synthesis process, leading to the inhibition of bacterial growth. Together, these two antibiotics work synergistically to effectively combat bacterial infections.

Side Effects

Common side effects may include diarrhea, nausea, vomiting, rash, and injection site reactions such as pain or redness. Notify your healthcare provider if these side effects persist or worsen.

Serious side effects are rare but can occur. These may include severe allergic reactions, such as difficulty breathing, swelling of the face or throat, or hives. If you experience any of these symptoms, seek immediate medical attention.

Drug Interactions

Tazobax TB may interact with other medications, including diuretics, other antibiotics, and certain medications used to treat myasthenia gravis. Inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential drug interactions.

Precautions

Before using Tazobax TB, inform your healthcare provider about any allergies, especially to cephalosporin or aminoglycoside antibiotics. Additionally, inform them about any medical conditions you have, such as kidney problems or hearing loss, as these may affect the use of this medication.

Tazobax TB should be used with caution in patients with pre-existing renal impairment, as dose adjustments may be necessary. Follow the dosing instructions provided by your healthcare provider.

Storage

Patient Tips

• Follow the prescribed dosage and administration instructions provided by your healthcare provider.
• If you miss a dose, contact your healthcare provider for guidance on how to proceed.
• Do not stop using Tazobax TB without consulting your healthcare provider, even if you start feeling better.
• Drink plenty of fluids while using this medication to help prevent kidney problems.
• Report any unusual symptoms or side effects to your healthcare provider promptly.
• Complete the full course of treatment, even if your symptoms improve before the medication is finished.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Ceftazidime 1g Powder for Solution for Injection or Infusion (Health Professionals SmPC) Available at:
• Ceftazidime injection (Drugs.com) [Accessed 2 Jun. 2024] (online) Available at:
• ceftazidime sodium in d5w piggyback (RX) [Accessed 11 Jun. 2024] (online) Available at:
• Ceftazidime and Avibactam Injection (MedlinePlus) [Accessed 20 Jun. 2024] (online) Available at:
• Wang Y, Wang J, Wang R, Cai Y. Resistance to ceftazidime-avibactam and underlying mechanisms. J Glob Antimicrob Resist. 2020 Sep;22:18-27. doi: 10.1016/j.jgar.2019.12.009. Epub 2019 Dec 19. [Accessed 8 Jun. 2024] Available at: