TMC Vaginal Pessaries

Introduction

TMC are a prescription medication containing three active ingredients: Clotrimazole, Miconazole, and Tinidazole. This combination of antifungal and antiprotozoal agents is commonly used to treat vaginal infections caused by fungi and certain types of bacteria. TMC are available under this brand name and are prescribed by healthcare professionals.

Uses

TMC are primarily prescribed for the treatment of vaginal infections, including vaginal yeast infections (caused by fungi such as Candida) and bacterial vaginosis (caused by certain bacteria). These infections can cause symptoms such as itching, burning, abnormal discharge, and discomfort in the vaginal area. TMC work by targeting and eliminating the infectious organisms, providing relief and promoting healing.

Dosage and Administration

TMC are intended for intravaginal use only. The usual recommended dosage is one pessary inserted deep into the vagina, preferably before bedtime. Follow the instructions provided by your healthcare professional regarding the duration of treatment. The pessary should be inserted using clean hands, and it may be helpful to lie down or remain in a reclined position for a short period after insertion to allow the pessary to dissolve properly.

Mechanism of Action

TMC contain three active ingredients with different mechanisms of action. Clotrimazole and Miconazole belong to a class of antifungal medications called azoles. They work by inhibiting the growth and reproduction of fungi, thereby eliminating the infection. Tinidazole, on the other hand, is an antiprotozoal agent that works by interfering with the DNA synthesis of certain types of bacteria and protozoa. Together, these ingredients provide a comprehensive approach to treating vaginal infections.

Side Effects

Common side effects that may occur include vaginal irritation, burning, itching, or redness at the site of application. These side effects are usually mild and temporary. If you experience any persistent or severe side effects, or if you notice any signs of an allergic reaction such as rash, swelling, or difficulty breathing, seek medical attention immediately.

Drug Interactions

inform your healthcare professional about all the medications you are currently taking, including over-the-counter drugs, supplements, and herbal products, as they may interact with TMC. While specific drug interactions for this combination are not widely reported, it is always prudent to consult your healthcare professional for guidance to ensure the safe and effective use of this medication.

Precautions

Before using TMC, inform your healthcare professional if you have any known allergies to Clotrimazole, Miconazole, Tinidazole, or any other ingredients in the pessary. Additionally, let your healthcare professional know about any existing medical conditions or if you are pregnant or breastfeeding. Avoid sexual intercourse during treatment with TMC, as it may interfere with the effectiveness of the medication or cause discomfort.

Storage

Patient Tips

• Follow the prescribed dosage and treatment duration as instructed by your healthcare professional, even if symptoms improve before completing the full course of treatment.
• Wash your hands thoroughly before and after using the pessaries to maintain good hygiene.
• If you have any questions or concerns about the medication or its use, do not hesitate to consult your healthcare professional.
• Avoid using tampons, douches, or other vaginal products during treatment with TMC, unless otherwise advised by your healthcare professional.
• If your symptoms worsen or do not improve after the prescribed treatment, contact your healthcare professional for further evaluation and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Clotrimazole: medicine used to treat fungal skin infections (NHS UK) [Accessed 25 Jun. 2024] (online) Available at:
• Boots Antifungal Cream (Health Professionals SmPC) Available at:
• Clotrimazole topical (Drugs.com) [Accessed 0 Jun. 2024] (online) Available at:
• athlete’s foot (clotrimazole) 1 % topical cream (OTC) [Accessed 27 Jun. 2024] (online) Available at:
• Clotrimazole Topical (MedlinePlus) [Accessed 24 Jun. 2024] (online) Available at:
• Crowley PD, Gallagher HC. Clotrimazole as a pharmaceutical: past, present and future. J Appl Microbiol. 2014 Sep;117(3):611-7. doi: 10.1111/jam.12554. Epub 2014 Jun 30. [Accessed 24 Jun. 2024] Available at: