Tubervac Vaccine

Introduction

Tubervac, also known by its generic name Bacillus Calmette-Guerin (BCG), is a vaccine used primarily for the prevention of tuberculosis (TB). It is a live attenuated vaccine that stimulates the immune system to protect against Mycobacterium tuberculosis, the bacterium that causes TB.

Uses

Tubervac is primarily prescribed for the prevention of tuberculosis. It is commonly used in individuals who are at high risk of developing active TB, such as infants, children, and healthcare workers. It is also recommended for individuals with a positive tuberculin skin test who have never received the vaccine before.

Dosage and Administration

Tubervac is administered as an injection into the upper arm, just below the shoulder. The dosage and administration schedule may vary depending on the individual’s age and risk factors. It is typically given as a single dose, but additional doses may be required in certain cases. Follow the healthcare provider’s instructions and complete the full course of vaccination for optimal protection.

Mechanism of Action

Tubervac works by introducing the weakened form of the bacterium Mycobacterium bovis, which is closely related to Mycobacterium tuberculosis, into the body. This stimulates the immune system to produce a protective response against TB. The vaccine helps the body recognize and fight off the TB bacteria more effectively, reducing the risk of developing active TB disease.

Side Effects

Like any vaccine, Common side effects include redness, swelling, or tenderness at the injection site. These side effects are usually mild and resolve on their own within a few days.

Serious side effects are rare but may include severe allergic reactions, such as difficulty breathing, rash, or swelling of the face, tongue, or throat. If any serious side effects occur, seek immediate medical attention.

Drug Interactions

Tubervac is generally safe to administer alongside most other medications. However, inform your healthcare provider about any other medications you are taking, as certain medications may interact with the vaccine and affect its effectiveness.

Precautions

Before receiving Tubervac, inform your healthcare provider if you have a history of severe allergic reactions, immune system disorders, or if you are pregnant or breastfeeding. These factors may affect the suitability and timing of vaccination.

Note that Tubervac is not recommended for individuals with an active TB infection, as it is intended for prevention rather than treatment.

Storage

Tubervac should be stored in a refrigerator between 2°C and 8°C (36°F and 46°F). It should be protected from light and kept in its original packaging until it is ready to be used. Do not freeze the vaccine.

Patient Tips

Here are some additional tips for patients using Tubervac:

• Inform your healthcare provider about any allergies or medical conditions you have before receiving the vaccine.
• Follow the recommended vaccination schedule and complete the full course of vaccination for optimal protection.
• If you experience any side effects or have any concerns after receiving the vaccine, contact your healthcare provider.
• Continue to practice good hygiene and take necessary precautions to prevent TB, even after receiving the vaccine.
• Keep track of your vaccine records and inform other healthcare providers about your vaccination status when necessary.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Sprains and strains (NHS UK) [Accessed 8 Jun. 2024] (online) Available at:
• BCG Vaccine AJV (Health Professionals SmPC) Available at:
• TICE BCG: Package Insert Prescribing Information (Drugs.com) [Accessed 30 Jun. 2024] (online) Available at:
• cholera vaccine, live suspension for reconstitution (RX) [Accessed 26 Jun. 2024] (online) Available at:
• BCG Vaccine Fact Sheet (Centers for Disease Control and Prevention) [Accessed 17 Jun. 2024] (online) Available at:
• Miyazaki J, Onozawa M, Takaoka E, Yano I. Bacillus Calmette-Guerin strain differences as the basis for immunotherapies against bladder cancer. Int J Urol. 2018 May;25(5):405-413. doi: 10.1111/iju.13538. Epub 2018 Mar 5. [Accessed 28 Jun. 2024] Available at: