Twinrix Adult Injection

Introduction

Twinrix Adult is a combination vaccine that contains freeze-dried live attenuated Hepatitis A Vaccine and Hepatitis B Vaccine. It is commonly known as a Hepatitis A and B combination vaccine. This vaccine is designed to provide protection against both Hepatitis A and Hepatitis B viruses.

Uses

Twinrix Adult is prescribed for the prevention of Hepatitis A and Hepatitis B infections. Hepatitis A is a viral infection that affects the liver and is usually transmitted through contaminated food or water. Hepatitis B is a viral infection that can lead to chronic liver disease and is transmitted through exposure to infected blood or body fluids. By vaccinating against both viruses, Twinrix Adult helps to reduce the risk of developing these serious infections.

Dosage and Administration

Twinrix Adult is administered as an injection, usually into the muscle of the upper arm. The recommended dosage and schedule may vary depending on the individual’s age and previous vaccination history. Follow the instructions provided by your healthcare professional or the vaccine manufacturer. They will determine the appropriate dosage and administration schedule for you.

Mechanism of Action

Twinrix Adult works by stimulating the immune system to produce antibodies against the Hepatitis A and Hepatitis B viruses. The vaccine contains weakened forms of the viruses, which are not capable of causing the diseases. When the vaccine is administered, the immune system recognizes these viruses as foreign and mounts an immune response. This response includes the production of antibodies that can neutralize and eliminate the viruses if the person is exposed to them in the future.

Side Effects

Common side effects may include pain or redness at the injection site, mild fever, headache, or fatigue. These side effects are usually mild and resolve on their own within a few days.

In rare cases, more serious side effects may occur. These can include allergic reactions, such as difficulty breathing, swelling of the face or throat, or hives. If you experience any severe or persistent side effects, seek medical attention immediately.

Drug Interactions

inform your healthcare professional about all the medications you are taking, including prescription, over-the-counter, and herbal products. Some medications may interact with Twinrix Adult and affect its effectiveness or increase the risk of side effects. It is particularly important to discuss any medications that suppress the immune system, as they may interfere with the vaccine’s ability to produce an immune response.

Precautions

Before receiving Twinrix Adult, inform your healthcare professional if you have any known allergies, especially to any components of the vaccine. Additionally, if you have a history of severe allergic reactions to vaccines or have a weakened immune system, you should discuss this with your healthcare professional.

Twinrix Adult should not be administered to individuals who are currently acutely ill or have a fever. Avoid this vaccine if you are pregnant or planning to become pregnant in the near future, as the safety of the vaccine during pregnancy has not been established.

Storage

Twinrix Adult should be stored in a refrigerator between 2°C and 8°C (36°F and 46°F). It should not be frozen. Keep the vaccine out of the reach of children and discard any unused portion after reconstitution, as directed by your healthcare professional.

Patient Tips

• If you are traveling to an area where Hepatitis A or Hepatitis B is prevalent, it is recommended to receive the vaccine at least two weeks before your trip.
• Follow the recommended vaccination schedule and complete the full course of the vaccine to ensure maximum protection.
• If you miss a scheduled dose, consult your healthcare professional for guidance on the best course of action.
• Inform your healthcare professional if you experience any unusual or persistent symptoms after receiving the vaccine.
• Remember that Twinrix Adult does not provide protection against other strains of Hepatitis or other infectious diseases. Continue practicing good hygiene and taking necessary precautions to prevent exposure to other viruses and bacteria.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Vaccinations (NHS UK) [Accessed 8 Jun. 2024] (online) Available at:
• Dukoral suspension and effervescent powder for oral suspension, Cholera vaccine (inactivated, oral) (Health Professionals SmPC) Available at:
• Cholera Vaccine Dosage Guide + Max Dose, Adjustments (Drugs.com) [Accessed 27 Jun. 2024] (online) Available at:
• cholera vaccine, live suspension for reconstitution (RX) [Accessed 26 Jun. 2024] (online) Available at:
• Cholera Vaccine (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Sit B, Fakoya B, Waldor MK. Emerging Concepts in Cholera Vaccine Design. Annu Rev Microbiol. 2022 Sep 8;76:681-702. doi: 10.1146/annurev-micro-041320-033201. Epub 2022 Jun 27. [Accessed 2 Jun. 2024] Available at: