Urihold S 50 Tablet ER

Introduction

Urihold S is a prescription medication that combines two active ingredients: Mirabegron and Solifenacin. It is available in the form of extended-release tablets.

Uses

Urihold S is primarily prescribed for the treatment of overactive bladder (OAB) symptoms in adults. OAB is a condition characterized by a sudden, frequent, and uncontrollable urge to urinate, accompanied by urinary incontinence (involuntary loss of urine) and increased urinary frequency.

Dosage and Administration

The recommended dosage of Urihold S is one tablet taken orally once daily, with or without food. Follow the instructions provided by your healthcare professional regarding the timing and duration of the treatment. Swallow the tablet whole without crushing or chewing it, as it is designed to release the medication slowly over time.

Mechanism of Action

Urihold S works by targeting two different receptors in the body. Mirabegron acts on beta-3 adrenergic receptors in the bladder, relaxing the smooth muscle and increasing bladder capacity. Solifenacin, on the other hand, works by blocking muscarinic receptors, which helps reduce bladder contractions and control the urge to urinate.

Side Effects

Common side effects may include dry mouth, constipation, blurred vision, and urinary tract infection. These side effects are usually mild and temporary. However, if you experience any severe or persistent side effects. Contact your healthcare provider immediately.

Drug Interactions

Urihold S may interact with certain medications, including but not limited to:

• Anticholinergic medications: Combining Urihold S with other medications that have anticholinergic effects may increase the risk of side effects such as dry mouth, constipation, and blurred vision.
• CYP3A4 inhibitors and inducers: Certain medications that affect the activity of the enzyme CYP3A4 may impact the levels of Mirabegron and Solifenacin in the body, potentially altering their effectiveness or increasing the risk of side effects.

Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid potential drug interactions.

Precautions

Before starting Urihold S, inform your healthcare provider if you have any pre-existing medical conditions, such as liver or kidney problems, urinary retention, or stomach or intestinal disorders. This medication may not be suitable for everyone, and your healthcare provider will assess the potential risks and benefits based on your individual circumstances.

Urihold S should be used with caution in elderly patients, as they may be more susceptible to certain side effects, such as confusion or memory problems.

Avoid alcohol consumption while taking this medication, as it may increase the risk of side effects.

Storage

Urihold S should be stored at room temperature, away from excess heat and moisture. Keep the medication out of the reach of children and pets. Do not use the medication if it has expired or if the tablets appear damaged or discolored.

Patient Tips

• Take Urihold S exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare professional.
• If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• It may take some time for Urihold S to provide its full benefits. Be patient and continue taking the medication as prescribed.
• Stay hydrated by drinking an adequate amount of fluids throughout the day, unless otherwise advised by your healthcare provider.
• If you experience any allergic reactions or severe side effects, such as difficulty breathing, swelling of the face or throat, or chest pain, seek immediate medical attention.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Mirabegron: medicine to treat the symptoms of an overactive bladder (NHS UK) [Accessed 6 Jun. 2024] (online) Available at:
• Betmiga 25 mg prolonged-release tablets (Health Professionals SmPC) Available at:
• Mirabegron (Drugs.com) [Accessed 5 Jun. 2024] (online) Available at:
• myrbetriq (mirabegron) (RX) [Accessed 13 Jun. 2024] (online) Available at:
• Mirabegron (MedlinePlus) [Accessed 30 Jun. 2024] (online) Available at:
• Keam SJ. Mirabegron: Pediatric First Approval. Paediatr Drugs. 2021 Jul;23(4):411-415. doi: 10.1007/s40272-021-00452-4. [Accessed 4 Jun. 2024] Available at: