Xafinact 50 Tablet

Introduction

Xafinact is a prescription medication that contains the active ingredient Safinamide. It is available in tablet form and is primarily used for the treatment of Parkinson’s disease.

Uses

Xafinact is prescribed to help manage the symptoms of Parkinson’s disease, a neurodegenerative disorder that affects movement and coordination. It can be used as an adjunct therapy in patients who are already taking levodopa or dopaminergic agents.

Dosage and Administration

The dosage of Xafinact may vary depending on individual patient factors and the specific guidance of the prescribing healthcare professional. Follow the instructions provided by your healthcare provider. Generally, the recommended starting dose for adults is 50 mg taken orally once daily. The dose may be adjusted based on individual response and tolerability, up to a maximum daily dose of 100 mg.

Xafinact should be taken with or without food, as directed by your healthcare provider. Swallow the tablet whole with a glass of water and do not crush, chew, or break it.

Mechanism of Action

Safinamide, the active ingredient in Xafinact, works by multiple mechanisms to help manage the symptoms of Parkinson’s disease. It is thought to inhibit the enzyme monoamine oxidase B (MAO-B), which leads to increased levels of dopamine in the brain. Dopamine is a neurotransmitter that plays a key role in regulating movement and coordination. By increasing dopamine levels, Xafinact helps to improve motor symptoms associated with Parkinson’s disease.

Side Effects

Common side effects may include nausea, constipation, dry mouth, dizziness, and headache. These side effects are usually mild and temporary. However, if they persist or become bothersome, inform your healthcare provider.

Serious side effects are rare but can occur. Contact your healthcare provider immediately if you experience any of the following: severe or persistent nausea or vomiting, hallucinations, confusion, mood changes, uncontrolled movements, or signs of an allergic reaction (such as rash, itching, swelling, severe dizziness, or difficulty breathing).

Drug Interactions

inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Xafinact may interact with certain medications, including antidepressants (such as selective serotonin reuptake inhibitors), MAO-B inhibitors, and other Parkinson’s disease medications. These interactions can affect the effectiveness or increase the risk of side effects. Your healthcare provider will carefully consider these interactions when prescribing Xafinact.

Precautions

Before starting Xafinact, inform your healthcare provider about any pre-existing medical conditions, including liver disease, heart problems, or a history of psychiatric disorders. Xafinact should be used with caution in these situations.

Xafinact is contraindicated in patients with severe liver impairment and those who are taking certain medications, such as monoamine oxidase inhibitors (MAOIs). Discuss your medical history and current medications with your healthcare provider to ensure the safe use of Xafinact.

Storage

Xafinact should be stored at room temperature, away from moisture and direct sunlight. Keep it out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Xafinact exactly as prescribed by your healthcare provider. Do not adjust the dose or stop taking the medication without consulting your doctor.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• It may take several weeks for the full effects of Xafinact to be noticeable. Be patient and continue taking the medication as prescribed.
• Avoid sudden discontinuation of Xafinact, as this may lead to worsening of symptoms. If you need to stop the medication, consult your healthcare provider for guidance.
• Inform your healthcare provider about any new or worsening symptoms, as well as any side effects you may experience while taking Xafinact.
• Follow a healthy lifestyle, including regular exercise and a balanced diet, as recommended by your healthcare provider.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Restless legs syndrome – Causes (NHS UK) [Accessed 30 Jun. 2024] (online) Available at:
• Dopamine 40 mg/ml Sterile Concentrate (Health Professionals SmPC) Available at:
• Dopamine (Drugs.com) [Accessed 0 Jun. 2024] (online) Available at:
• aplenzin 522 mg tablet,extended release antidepressant dopamine norepinephrine reuptake inhibitors (RX) [Accessed 13 Jun. 2024] (online) Available at:
• DRD5 gene (MedlinePlus) [Accessed 12 Jun. 2024] (online) Available at:
• Lerner TN, Holloway AL, Seiler JL. Dopamine, Updated: Reward Prediction Error and Beyond. Curr Opin Neurobiol. 2021 Apr;67:123-130. doi: 10.1016/j.conb.2020.10.012. Epub 2020 Nov 14. [Accessed 13 Jun. 2024] Available at: