Zavicefta Injection

Introduction

Zavicefta is a prescription medication that contains two active ingredients: Ceftazidime and Avibactam. It is primarily used to treat infections caused by certain bacteria that are resistant to other antibiotics. Zavicefta is available under various brand names.

Uses

Zavicefta is prescribed to treat a range of infections caused by bacteria that are resistant to other antibiotics. It is commonly used for the treatment of complicated urinary tract infections, including kidney infections (pyelonephritis). Zavicefta may also be used to treat infections in the abdomen, lungs, and skin.

Dosage and Administration

Zavicefta should be administered by a healthcare professional, typically in a hospital or clinic setting. The dosage and duration of treatment will depend on the specific infection being treated, as well as the patient’s age, weight, and overall health. Follow the healthcare professional’s instructions and complete the full course of treatment.

Mechanism of Action

The active ingredients in Zavicefta, Ceftazidime and Avibactam, work together to combat bacterial infections. Ceftazidime is a cephalosporin antibiotic that inhibits the growth of bacteria by interfering with the synthesis of their cell walls. Avibactam, on the other hand, is a beta-lactamase inhibitor that prevents certain enzymes produced by bacteria from breaking down Ceftazidime, thus enhancing its effectiveness.

Side Effects

Common side effects may include diarrhea, nausea, vomiting, headache, and rash. These side effects are usually mild and go away on their own. However, if they persist or become severe, consult a healthcare professional.

In rare cases, Zavicefta may cause more serious side effects, such as allergic reactions, severe skin reactions, or changes in kidney function. If any of these serious side effects occur, immediate medical attention is necessary.

Drug Interactions

Zavicefta may interact with other medications, including certain antibiotics, anticoagulants, or medications that affect the kidneys. Inform the healthcare professional about all the medications, supplements, and herbal products you are taking before starting treatment with Zavicefta.

Precautions

Before using Zavicefta, inform the healthcare professional about any existing medical conditions, such as kidney disease or allergies. Zavicefta may not be suitable for everyone, and certain precautions should be taken to ensure its safe use.

Zavicefta is contraindicated in individuals with a known allergy to Ceftazidime, Avibactam, or other cephalosporin antibiotics. Additionally, it should be used with caution in individuals with a history of severe allergic reactions to other beta-lactam antibiotics.

Storage

Patient Tips

• Follow the dosage instructions provided by the healthcare professional and complete the full course of treatment, even if you start to feel better.
• If you experience any unusual or persistent side effects, contact your healthcare professional.
• Inform your healthcare professional about all the medications, supplements, and herbal products you are taking before starting treatment with Zavicefta.
• Keep all follow-up appointments with your healthcare professional to monitor your progress and response to the medication.
• Store Zavicefta properly, following the instructions provided, to maintain its effectiveness and safety.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Ceftazidime 1g Powder for Solution for Injection or Infusion (Health Professionals SmPC) Available at:
• Avibactam and cefTAZidime (Drugs.com) [Accessed 15 Jun. 2024] (online) Available at:
• ceftazidime-avibactam solution, reconstituted (recon soln) (RX) [Accessed 22 Jun. 2024] (online) Available at:
• Ceftazidime and Avibactam Injection (MedlinePlus) [Accessed 1 Jun. 2024] (online) Available at:
• van Duin D, Bonomo RA. Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation beta-Lactam/beta-Lactamase Inhibitor Combinations. Clin Infect Dis. 2016 Jul 15;63(2):234-41. doi: 10.1093/cid/ciw243. Epub 2016 Apr 20. [Accessed 30 Jun. 2024] Available at: