Zeopant LS 75mg/40mg Capsule SR

Introduction

Zeopant LS is a prescription medication that contains two active ingredients: Levosulpiride and Pantoprazole. Levosulpiride is a selective dopamine D2 receptor antagonist that helps regulate gastrointestinal motility and reduces nausea and vomiting. Pantoprazole belongs to a class of medications known as proton pump inhibitors, which work by reducing the production of stomach acid. Zeopant LS is primarily used to manage conditions such as gastroesophageal reflux disease (GERD), gastritis, and dyspepsia.

Uses

Zeopant LS is prescribed to treat a range of conditions related to the digestive system. It is commonly used for the following:

• Gastroesophageal reflux disease (GERD): Zeopant LS helps reduce the symptoms of GERD, such as heartburn, acid reflux, and regurgitation.
• Gastritis: This medication can be used to manage the inflammation of the stomach lining caused by gastritis, which may lead to symptoms like abdominal pain, nausea, and indigestion.
• Dyspepsia: Zeopant LS may be prescribed to relieve symptoms of dyspepsia, including bloating, discomfort, and early satiety.

Note that Zeopant LS should only be used under the guidance of a healthcare professional.

Dosage and Administration

• The dosage of Zeopant LS may vary depending on the specific condition being treated and individual patient factors. Follow the instructions provided by your healthcare provider.
• The capsules should be swallowed whole with a glass of water, preferably before meals.
• Do not crush, chew, or break the capsules, as this may affect the medication’s effectiveness.

Mechanism of Action

Levosulpiride, one of the active ingredients in Zeopant LS, acts as a selective dopamine D2 receptor antagonist. By blocking these receptors, it helps regulate gastrointestinal motility, reducing symptoms such as nausea, vomiting, and gastric stasis. Pantoprazole, the other active ingredient, is a proton pump inhibitor. It works by reducing the production of stomach acid, thereby relieving symptoms associated with excessive acid production.

Side Effects

Zeopant LS may cause some side effects in certain individuals. Be aware of these potential side effects, which can be categorized as common and serious:

Common side effects may include:

• Nausea
• Headache
• Diarrhea
• Abdominal pain
• Dizziness
• Dry mouth

Serious side effects are rare but may include:

• Allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
• Abnormal heart rhythm
• Unusual muscle movements or stiffness
• Signs of liver problems (e.g., yellowing of the skin or eyes, dark urine, persistent nausea)

If you experience any of these serious side effects or any other unusual symptoms, seek medical attention immediately.

Drug Interactions

Zeopant LS may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. Some common and serious drug interactions to be aware of include:

• Medications that affect gastric pH (e.g., antacids, proton pump inhibitors, H2 blockers): These may affect the absorption and effectiveness of Zeopant LS.
• Medications that prolong the QT interval (e.g., certain antibiotics, antifungals, antidepressants): Combining these medications with Zeopant LS may increase the risk of abnormal heart rhythm.

Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid potential drug interactions.

Precautions

Before using Zeopant LS, consider the following precautions:

• Contraindications: This medication is contraindicated in individuals with a known hypersensitivity to Levosulpiride, Pantoprazole, or any other components of the formulation. It should also be avoided in patients with a history of prolactin-dependent tumors or gastrointestinal bleeding.
• Pregnancy and breastfeeding: Zeopant LS should be used with caution during pregnancy and breastfeeding. Consult with your healthcare provider to weigh the potential benefits and risks before using this medication.
• Other medical conditions: Inform your healthcare provider about any other medical conditions you have, especially liver disease, renal impairment, or any history of allergic reactions.

Storage

Zeopant LS should be stored in a cool, dry place away from direct sunlight. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or shows any signs of damage or deterioration.

Patient Tips

• Take Zeopant LS exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your doctor.
• If you forget to take a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• maintain a healthy lifestyle and follow any dietary or lifestyle modifications recommended by your healthcare provider while taking Zeopant LS.
• If you have any questions or concerns about your medication, do not hesitate to contact your healthcare provider or pharmacist for guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Pantoprazole: medicine to lower stomach acid (NHS UK) [Accessed 21 Jun. 2024] (online) Available at:
• Pantoloc Control 20mg gastro-resistant tablets (Health Professionals SmPC) Available at:
• Levosulpiride (International database) (Drugs.com) [Accessed 7 Jun. 2024] (online) Available at:
• pantoprazole sodium (RX) [Accessed 11 Jun. 2024] (online) Available at:
• Pantoprazole (MedlinePlus) [Accessed 15 Jun. 2024] (online) Available at:
• Arshad A, Irfan M, Inam M, Hussain NHN, Ismail SB. Levosulpiride for Premature Ejaculation: A Systematic Review and Meta-Analysis. Am J Mens Health. 2022 Sep-Oct;16(5):15579883221124832. doi: 10.1177/15579883221124832. [Accessed 8 Jun. 2024] Available at: