Zerodol-MR Tablet

Introduction

Zerodol-MR is a prescription medication that contains two active ingredients: Aceclofenac and Tizanidine. It is commonly used to provide relief from pain and muscle spasms associated with various conditions.

Uses

Zerodol-MR is primarily prescribed to manage pain and muscle spasms caused by conditions such as:

• Musculoskeletal disorders, including sprains, strains, and muscle injuries
• Osteoarthritis, a degenerative joint disease that causes pain and inflammation
• Rheumatoid arthritis, an autoimmune disease that affects the joints
• Fibromyalgia, a chronic pain disorder characterized by widespread musculoskeletal pain

note that this medication should only be used under the guidance of a healthcare professional, as they will determine if it is suitable for your specific condition.

Dosage and Administration

The dosage of Zerodol-MR may vary depending on the severity of your symptoms and your individual response to the medication. Follow your healthcare provider’s instructions regarding the dosage and duration of treatment. Typically, the recommended dosage for adults is one tablet taken orally, with or without food, twice daily.

Mechanism of Action

Zerodol-MR contains two active ingredients, Aceclofenac and Tizanidine, which work together to provide pain relief and reduce muscle spasms. Aceclofenac belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the production of certain substances in the body that cause pain and inflammation. Tizanidine is a muscle relaxant that acts on the central nervous system to reduce muscle spasms and improve muscle function.

Side Effects

Common side effects may include:

• Nausea
• Upset stomach
• Drowsiness
• Dizziness
• Headache

If any of these side effects persist or worsen, consult your healthcare provider. In some cases, Zerodol-MR may cause more serious side effects, such as allergic reactions, gastrointestinal bleeding, or liver problems. If you experience any severe or unusual symptoms, seek immediate medical attention.

Drug Interactions

Zerodol-MR may interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins. Common drug interactions may occur with:

• Other NSAIDs, such as aspirin or ibuprofen
• Blood thinners, such as warfarin
• Antidepressants, such as fluoxetine or sertraline
• Muscle relaxants, such as baclofen or cyclobenzaprine

follow your healthcare provider’s advice and inform them of any changes in your medication regimen to avoid potential interactions.

Precautions

Before taking Zerodol-MR, inform your healthcare provider about any pre-existing medical conditions or allergies you may have. Certain precautions should be taken into consideration, including:

• Contraindications: Zerodol-MR should not be used if you have a known hypersensitivity to Aceclofenac, Tizanidine, or any other ingredients in the medication. It is also contraindicated in patients with a history of gastrointestinal bleeding, severe liver or kidney impairment, or a history of asthma or allergic reactions to NSAIDs.
• Pregnancy and breastfeeding: Zerodol-MR should be used with caution during pregnancy and breastfeeding, as it may have potential risks for the unborn baby or nursing infant. Consult your healthcare provider for guidance.
• Interactions with other medications: As mentioned earlier, Zerodol-MR may interact with certain medications. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.

Storage

Zerodol-MR should be stored at room temperature, away from moisture and direct sunlight. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging appears to be tampered with.

Patient Tips

• Take the medication exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage or duration of treatment.
• If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Avoid consuming alcohol while taking Zerodol-MR, as it may increase the risk of certain side effects.
• monitor your response to the medication and report any unusual or severe symptoms to your healthcare provider.
• If you have any questions or concerns about your treatment with Zerodol-MR, do not hesitate to discuss them with your healthcare provider.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Aceclofenac 100 mg Film-coated Tablets (Health Professionals SmPC) Available at:
• ACECLOFENAC 100MG TABLETS (Drugs.com) [Accessed 11 Jun. 2024] (online) Available at:
• comfort pac-tizanidine kit (RX) [Accessed 0 Jun. 2024] (online) Available at:
• Tizanidine (MedlinePlus) [Accessed 10 Jun. 2024] (online) Available at:
• Negi S, Tandel N, Sharma P, Kumar R, Tyagi RK. Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation. Drug Discov Today. 2023 Aug;28(8):103671. doi: 10.1016/j.drudis.2023.103671. Epub 2023 Jun 16. [Accessed 25 Jun. 2024] Available at: