Introduction
Zolset D is a prescription medication that combines two active ingredients: Domperidone and Rabeprazole. Domperidone is a prokinetic agent that helps to improve gastrointestinal motility, while Rabeprazole is a proton pump inhibitor that reduces the production of stomach acid. This combination medication is primarily used to treat conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers.
Uses
Zolset D is prescribed to manage symptoms associated with GERD, such as heartburn, regurgitation, and difficulty swallowing. It is also used to treat peptic ulcers, which are sores that develop in the lining of the stomach or small intestine. This medication helps to reduce stomach acid production, relieve symptoms, and promote healing of the affected areas.
Dosage and Administration
Zolset D should be taken as directed by your healthcare provider. The usual recommended dose for adults is one capsule once daily, preferably before a meal. Swallow the capsule whole with a glass of water, without crushing or chewing it. If you have difficulty swallowing the capsule, you may open it and sprinkle the contents onto a spoonful of soft food (e.g., applesauce) and swallow it immediately, without chewing.
Mechanism of Action
Domperidone in Zolset D works by blocking dopamine receptors in the digestive system, which enhances the movement of food through the stomach and intestines. This helps to relieve symptoms such as nausea, vomiting, and bloating. Rabeprazole, on the other hand, inhibits the enzyme responsible for the final step in gastric acid secretion, leading to a reduction in stomach acid production. By suppressing acid secretion, it helps to alleviate symptoms of GERD and promote healing of peptic ulcers.
Side Effects
Common side effects may include headache, dizziness, diarrhea, and stomach pain. These side effects are usually mild and temporary, but if they persist or worsen, consult your healthcare provider.
In rare cases, Zolset D can cause more serious side effects, such as allergic reactions, irregular heartbeat, or severe abdominal pain. If you experience any of these serious side effects, seek immediate medical attention.
Drug Interactions
Zolset D may interact with other medications, including antifungal agents, antibiotics, and certain antidepressants. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential interactions that may affect the effectiveness or safety of Zolset D.
Precautions
Before taking Zolset D, inform your healthcare provider about any known allergies or medical conditions you may have, especially if you have a history of liver disease or abnormal heart rhythm. This medication may not be suitable for everyone, and your healthcare provider will assess the risks and benefits based on your individual circumstances.
Zolset D should be used with caution in pregnant or breastfeeding women, and discuss the potential risks with your healthcare provider before starting this medication.
Storage
Patient Tips
- Take Zolset D exactly as prescribed by your healthcare provider. Do not take more or less than the recommended dose.
- If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
- maintain a healthy lifestyle, including a balanced diet and regular exercise, to support the effectiveness of Zolset D in managing your condition.
- If you experience any new or worsening symptoms while taking this medication, contact your healthcare provider for further evaluation.
- Do not share your medication with others, even if they have similar symptoms. Each individual’s condition may require specific treatment.
Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.
References
- Domperidone: anti-sickness medicine for nausea and vomiting (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
- Domperidone 10 mg film-coated tablets (Health Professionals SmPC) Available at:
- Domperidone (Drugs.com) [Accessed 4 Jun. 2024] (online) Available at:
- rabeprazole sodium (RX) [Accessed 26 Jun. 2024] (online) Available at:
- Definitions of Digestive Terms (International Foundation for Gastrointestinal Disorders) [Accessed 3 Jun. 2024] (online) Available at:
- Puoti MG, Assa A, Benninga M, Broekaert IJ, Carpi FJM, Deganello Saccomani M, Dolinsek J, Homan M, Mas E, Miele E, Tzivinikos C, Thomson M, Borrelli O. Drugs in Focus: Domperidone. J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):e13-e22. doi: 10.1097/MPG.0000000000003822. Epub 2023 May 9. [Accessed 7 Jun. 2024] Available at:
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