Zomelis-DM 500 Tablet SR

Introduction

Zomelis-DM is a prescription medication that combines three active ingredients: Dapagliflozin, Metformin, and Vildagliptin. It is available in tablet form and is primarily used to manage type 2 diabetes mellitus.

Uses

Zomelis-DM is prescribed to control blood sugar levels in adults with type 2 diabetes. It is typically used alongside a healthy diet and regular exercise to help improve glycemic control.

Dosage and Administration

The dosage of Zomelis-DM will vary depending on individual patient needs and response to treatment. Follow your healthcare provider’s instructions regarding the dosage and frequency of administration. Typically, the recommended starting dose is one tablet taken orally once a day, with or without food. Your doctor may adjust the dose as needed to achieve optimal blood sugar control.

Mechanism of Action

Zomelis-DM works through a combination of its active ingredients. Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that helps to lower blood glucose levels by reducing the reabsorption of glucose in the kidneys and increasing urinary glucose excretion. Metformin is a biguanide that works by decreasing hepatic glucose production and improving insulin sensitivity. Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps to increase insulin secretion and decrease glucagon release.

Side Effects

Common side effects may include urinary tract infections, increased urination, hypoglycemia (low blood sugar), gastrointestinal disturbances (such as nausea, diarrhea, or stomach discomfort), and upper respiratory tract infections. Note that not all individuals will experience these side effects. If any side effects occur or persist, it is recommended to consult your healthcare provider.

Serious side effects are rare but may include lactic acidosis (a buildup of lactic acid in the blood), allergic reactions, pancreatitis, and severe joint pain. If you experience any signs of a serious side effect, such as difficulty breathing, swelling, severe abdominal pain, or persistent joint pain, seek immediate medical attention.

Drug Interactions

Zomelis-DM may interact with other medications, including certain antibiotics, antifungal agents, diuretics, and blood pressure medications. Inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Your doctor can determine if any potential drug interactions may occur and adjust your treatment plan accordingly.

Precautions

Before starting Zomelis-DM, inform your healthcare provider about any medical conditions you have, especially if you have a history of kidney problems, liver disease, heart disease, or pancreatitis. This medication may not be suitable for everyone, and your doctor will assess the risks and benefits before prescribing it.

Zomelis-DM should not be used in individuals with type 1 diabetes or diabetic ketoacidosis. Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of lactic acidosis.

Storage

Patient Tips

• Take Zomelis-DM exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor.
• Continue to follow a healthy diet and exercise routine as recommended by your healthcare provider.
• Monitor your blood sugar levels regularly as advised by your doctor.
• Keep an eye out for any unusual symptoms or side effects and report them to your healthcare provider.
• Attend regular check-ups with your doctor to assess the effectiveness of the medication and make any necessary adjustments to your treatment plan.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• About dapagliflozin (NHS UK) [Accessed 1 Jun. 2024] (online) Available at:
• Forxiga 10 mg film-coated tablets (Health Professionals SmPC) Available at:
• Dapagliflozin (Drugs.com) [Accessed 24 Jun. 2024] (online) Available at:
• dapagliflozin propaned 10 mg-metformin er 1,000 mg tablet,ext rel 24hr antihyperglycemic-sod/gluc cotransport-2 (sglt2) inhibitors (RX) [Accessed 23 Jun. 2024] (online) Available at:
• Dapagliflozin (MedlinePlus) [Accessed 25 Jun. 2024] (online) Available at:
• Dhillon S. Dapagliflozin: A Review in Type 2 Diabetes. Drugs. 2019 Jul;79(10):1135-1146. doi: 10.1007/s40265-019-01148-3. [Accessed 15 Jun. 2024] Available at: