Zovanta 30mg/40mg Tablet

Introduction

Zovanta is a prescription medication that contains two active ingredients: Domperidone and Pantoprazole. Domperidone is a prokinetic agent that helps improve gastrointestinal motility, while Pantoprazole is a proton pump inhibitor that reduces stomach acid production. This combination medication is primarily used to treat gastrointestinal conditions such as acid reflux, heartburn, and gastric ulcers. It is available under the brand name “Zovanta.”

Uses

Zovanta is prescribed for the following conditions:

• Gastroesophageal reflux disease (GERD)
• Gastric ulcers
• Dyspepsia (indigestion)
• Acid reflux
• Heartburn

This medication helps relieve symptoms such as regurgitation, heartburn, and stomach discomfort associated with these conditions.

Dosage and Administration

• The usual recommended dosage for adults is one tablet of Zovanta taken orally, once daily, before a meal.
• The tablet should be swallowed whole with a glass of water and should not be crushed or chewed.
• The duration of treatment may vary depending on the severity of the condition and the response to the medication. Follow the instructions provided by your healthcare provider.

Mechanism of Action

Zovanta works by combining the actions of its two active ingredients, Domperidone and Pantoprazole.

• Domperidone acts as a prokinetic agent, meaning it enhances the movement of the digestive system. It works by blocking dopamine receptors in the brain and gut, which helps accelerate the movement of food through the stomach and intestines. This can help relieve symptoms such as bloating, nausea, and vomiting.
• Pantoprazole is a proton pump inhibitor that reduces the production of stomach acid. It works by inhibiting the enzyme responsible for acid production in the stomach, thereby reducing acidity levels. This can help alleviate symptoms such as heartburn and gastric ulcers.

Side Effects

Common side effects may include:

• Nausea
• Headache
• Diarrhea
• Abdominal pain
• Dizziness

If any of these side effects persist or worsen, consult your healthcare provider. In rare cases, Zovanta may cause more serious side effects such as irregular heartbeat, muscle stiffness, or allergic reactions. If you experience any of these serious side effects, seek immediate medical attention.

Drug Interactions

Zovanta may interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some common drug interactions may include:

• Ketoconazole
• Clarithromycin
• Fluoxetine
• Warfarin

These are not the only possible interactions, so consult your healthcare provider or pharmacist for a comprehensive list of potential drug interactions.

Precautions

Before taking Zovanta, consider the following precautions:

• Inform your healthcare provider about any known allergies to Domperidone, Pantoprazole, or any other medications.
• Discuss any existing medical conditions, especially liver or kidney problems, with your healthcare provider before starting this medication.
• Zovanta may not be suitable for use during pregnancy or while breastfeeding. Consult your healthcare provider for guidance.

Storage

Zovanta should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use Zovanta beyond the expiration date printed on the packaging.

Patient Tips

• Take Zovanta exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage or duration of treatment.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• maintain a healthy lifestyle, including a balanced diet and regular exercise, to support the effectiveness of Zovanta in managing gastrointestinal conditions.
• If you have any concerns or questions about your treatment with Zovanta, do not hesitate to consult your healthcare provider or pharmacist for guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Domperidone: anti-sickness medicine for nausea and vomiting (NHS UK) [Accessed 10 Jun. 2024] (online) Available at:
• Domperidone 10 mg film-coated tablets (Health Professionals SmPC) Available at:
• Domperidone (Drugs.com) [Accessed 4 Jun. 2024] (online) Available at:
• pantoprazole sodium (RX) [Accessed 11 Jun. 2024] (online) Available at:
• Definitions of Digestive Terms (International Foundation for Gastrointestinal Disorders) [Accessed 3 Jun. 2024] (online) Available at:
• Puoti MG, Assa A, Benninga M, Broekaert IJ, Carpi FJM, Deganello Saccomani M, Dolinsek J, Homan M, Mas E, Miele E, Tzivinikos C, Thomson M, Borrelli O. Drugs in Focus: Domperidone. J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):e13-e22. doi: 10.1097/MPG.0000000000003822. Epub 2023 May 9. [Accessed 7 Jun. 2024] Available at: