Colesevelam

Colesevelam is a non-absorbable, hydrophilic, ion exchange resin that is specifically designed to lower cholesterol levels in the blood. It works by binding to bile acids in the digestive system, preventing their absorption and promoting their excretion. As a result, the body needs to convert more cholesterol into bile acids, thereby reducing the overall cholesterol levels in the blood.
Colesevelam is primarily used as an adjunct to diet and exercise for the treatment of high cholesterol, also known as hypercholesterolemia. It is typically prescribed to patients who have not achieved adequate cholesterol lowering with dietary modifications and statin therapy alone. By reducing the levels of low-density lipoprotein (LDL) cholesterol, colesevelam helps decrease the risk of cardiovascular events, such as heart attack and stroke, in patients with elevated cholesterol levels.
The medication is available in both tablet and powder forms, with the powder form being particularly useful for patients who have difficulty swallowing tablets. Colesevelam is usually taken once daily, with the dose depending on the individual’s specific cholesterol levels and medical history.
In addition to lowering cholesterol, colesevelam may also help manage blood sugar levels in patients with type 2 diabetes. This is because the increased conversion of cholesterol to bile acids can result in reduced hepatic glucose production and improved insulin sensitivity.
Colesevelam is generally well-tolerated, with the most common side effects being constipation, bloating, and abdominal pain. These side effects are typically mild and can be alleviated by increasing fluid intake and dietary fiber consumption. However, patients should consult with their healthcare provider if these side effects persist or worsen.