Trioxasalen

Trioxasalen is a combination medication containing three active ingredients: psoralen, 8-methoxysoralen, and 5-methoxysoralen. These compounds belong to a class of drugs called photosensitizing agents, which are used primarily in photochemotherapy for the treatment of certain skin conditions.
Photochemotherapy, also known as PUVA therapy, involves the combination of oral administration of Trioxasalen and exposure to ultraviolet A (UVA) light. The medication increases the skin’s sensitivity to UVA radiation, which in turn helps to alleviate symptoms and improve the appearance of affected skin areas.
Trioxasalen is commonly prescribed for the treatment of chronic skin conditions such as psoriasis, vitiligo, and mycosis fungoides. It is also used in the management of cutaneous T-cell lymphoma. The medication works by inducing apoptosis, or programmed cell death, in affected skin cells, thereby reducing inflammation, redness, and scaling.
Before starting Trioxasalen therapy, inform your healthcare provider of any pre-existing medical conditions, allergies, or current medications to ensure the safe and effective use of this medication. While undergoing photochemotherapy, avoid direct sunlight and wear protective clothing and sunscreen to minimize the risk of side effects such as skin irritation, burning, and increased sensitivity to light.