Metoclopramide

Metoclopramide, a gastrointestinal prokinetic agent, is a medication primarily used to alleviate symptoms of gastroesophageal reflux disease (GERD) and to facilitate gastric emptying. It is also employed to treat nausea and vomiting, particularly in postoperative patients and those experiencing morning sickness during pregnancy.
Metoclopramide acts by stimulating the motility of the upper gastrointestinal tract, promoting the movement of food through the stomach and small intestine. This action aids in the relief of symptoms associated with GERD, such as heartburn and regurgitation. Additionally, the medication helps to reduce the duration of nausea and vomiting by enhancing gastric emptying and decreasing the sensitivity of the chemoreceptor trigger zone in the brain.
Metoclopramide is available in various forms, including oral tablets, oral solution, and intramuscular and subcutaneous injections. The oral route is typically preferred for treating GERD and nausea, while the injectable forms are more suitable for patients who cannot tolerate oral medications or require rapid relief of symptoms.