Pyrimethamine, Sulphadoxine

Pyrimethamine and Sulphadoxine are two antimalarial medications commonly used together to treat and prevent malaria, a disease caused by parasites transmitted through mosquito bites. This combination medication, often referred to as Fansidar, works by inhibiting the growth and reproduction of the parasites responsible for malaria.
Pyrimethamine is a synthetic antimalarial drug that belongs to the class of drugs called folic acid antagonists. It works by blocking the synthesis of folic acid, a vitamin essential for the growth and survival of the parasites. By interrupting this process, pyrimethamine prevents the parasites from multiplying and causing further illness.
Sulphadoxine, on the other hand, is a sulfonamide antibiotic that inhibits the growth of the parasites by interfering with their ability to produce essential proteins. This medication also works against the parasites responsible for causing malaria, contributing to the overall effectiveness of the combination.
Fansidar, the combination of Pyrimethamine and Sulphadoxine, is typically used in the treatment of uncomplicated malaria caused by Plasmodium falciparum, the most severe and life-threatening form of the disease. This medication is also used as a preventative measure for individuals traveling to areas where malaria is prevalent, particularly during the malaria season.
Follow the prescribed dosage and administration instructions for this medication, as well as to complete the full course of treatment, even if symptoms have improved. Failure to do so may result in the persistence of the parasites and the development of drug resistance.