Pancuronium

Pancuronium is a non-depolarizing neuromuscular blocking agent used in anesthesia and surgical procedures. It is a synthetic quaternary ammonium compound derived from curare, a naturally occurring substance with muscle-relaxing properties. Pancuronium works by competitively binding to the nicotinic acetylcholine receptors at the neuromuscular junction, thereby blocking the transmission of nerve impulses and causing muscle paralysis.
As a paralytic agent, pancuronium is primarily used in conjunction with general anesthesia to facilitate intubation, provide muscle relaxation during surgery, and prevent patient movement or discomfort. It is particularly useful in procedures that require a high degree of muscle relaxation, such as orthopedic surgeries or certain cardiothoracic procedures.
Pancuronium has a relatively long duration of action, with an onset of around 2-3 minutes and a duration of 30-60 minutes. This makes it suitable for procedures that require sustained muscle relaxation. The drug is typically administered intravenously and is available in various concentrations, such as 0.2 mg/mL and 0.4 mg/mL.
Pancuronium does not provide analgesia or sedation, and its use should be accompanied by appropriate anesthetic and sedative agents. Additionally, the drug can cause histamine release, leading to symptoms such as flushing, hypotension, and bradycardia. Therefore, monitor the patient’s vital signs during administration and to adjust the dosage accordingly to ensure patient safety.