Amantadine

Amantadine, an antiviral medication, belongs to the adamantane class of drugs. It is predominantly used to prevent and treat influenza A, specifically the seasonal illness as well as the highly virulent H1N1 strain. Amantadine operates by inhibiting viral particle replication within host cells. Notably, it does not showcase antiviral activity against the currently circulating strains of the COVID-19 virus.
This pharmacological agent is often repurposed for the treatment of several neurological conditions such as Parkinson’s disease, a motor disorder characterized by tremors and slowed movement. Amantadine’s mode of action in these patients is thought to involve an amelioration of muscle rigidity through a dopamine release process in the brain. Contrary to its antiviral impact, this medication does not eliminate viruses but rather attenuates the symptoms associated with infection or illness.
Amantadine can be administered orally and metabolized in the liver; thus, caution is recommended with dosing in individuals exhibiting hepatic dysfunction or taking concomitant medication affecting liver function. Although commonly well-tolerated, it occasionally triggers side effects like lightheadedness, dizziness, sedation, and gastrointestinal issues.