Aceclofenac, Pregabalin

Aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID), helps to reduce inflammation and pain caused by various conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and dysmenorrhea. It works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which are involved in the production of prostaglandins that mediate inflammation and pain responses in the body.
Pregabalin, an anticonvulsant and analgesic agent, works by binding to the alpha 2 delta (α2δ) subunit of voltage-gated calcium channels in the central nervous system (CNS). This binding results in decreased calcium influx into nerve cells, leading to a reduction in pain signals and the release of neurotransmitters, such as glutamate and substance P, which mediate pain and inflammation pathways.
The combination of aceclofenac and pregabalin offers a comprehensive approach to treating patients with chronic pain, such as back pain, neuropathic pain, and osteoarthritis, by addressing both the underlying inflammation and nerve pain mechanisms. The medication is intended to improve patient outcomes and overall quality of life while managing potential side effects associated with either agent when used alone. However, the use of this combination medication is only appropriate for patients who have not experienced sufficient pain relief from monotherapy options.
It is important for patients using this medication to adhere to the prescribed dose, inform their healthcare provider of any prior medication allergies, and discontinue use if they experience an adverse reaction. As with all medications, patients should consult their healthcare professional to determine the most appropriate and effective treatment plan for their specific condition.