Actilyse 50mg Injection

Introduction

Actilyse is a prescription medication that contains the active ingredient Alteplase. It is available under the brand name Actilyse. This medication is primarily used in the treatment of certain blood clotting disorders.

Uses

Actilyse is prescribed for the following conditions:

• Acute ischemic stroke: It is used to dissolve blood clots that have formed in the blood vessels of the brain, helping to restore blood flow and minimize damage caused by the stroke.
• Acute myocardial infarction: It is used to dissolve blood clots that have formed in the blood vessels of the heart, helping to restore blood flow and prevent further damage to the heart muscle.
• Pulmonary embolism: It is used to dissolve blood clots that have traveled to the lungs, improving blood flow and preventing further complications.

Dosage and Administration

• The dosage of Actilyse may vary depending on the specific condition being treated. Follow the instructions provided by your healthcare professional.
• Actilyse is administered intravenously (into a vein) under the supervision of a healthcare professional.
• The exact dosage and duration of treatment will be determined by your healthcare professional based on your specific medical condition and response to the medication.

Mechanism of Action

Actilyse contains Alteplase, which is a type of medication known as a tissue plasminogen activator. It works by activating the production of plasmin, an enzyme that helps dissolve blood clots. By dissolving blood clots, Actilyse helps to restore blood flow in the affected areas and prevent further complications.

Side Effects

Some common side effects of Actilyse may include:

• Bleeding: Since Actilyse works by promoting clot dissolution, it can increase the risk of bleeding. This can manifest as easy bruising, nosebleeds, prolonged bleeding from cuts, or bleeding gums.
• Nausea and vomiting
• Headache
• Fever

Serious side effects may include:

• Severe bleeding: This can manifest as bleeding from the stomach or intestines, bleeding in the brain, or bleeding in other critical organs. Signs of severe bleeding may include black, tarry stools, vomiting blood, severe headache, or sudden weakness.
• Allergic reactions: Rarely, Actilyse may cause severe allergic reactions, including difficulty breathing, swelling of the face or throat, or rash.

If you experience any serious side effects or allergic reactions, seek immediate medical attention.

Drug Interactions

inform your healthcare professional about all the medications you are taking, including prescription, over-the-counter, and herbal products. Some medications may interact with Actilyse and affect its effectiveness or increase the risk of side effects. Common drug interactions may include:

• Anticoagulant medications (such as warfarin): These medications can increase the risk of bleeding when taken with Actilyse.
• Antiplatelet medications (such as aspirin or clopidogrel): These medications can also increase the risk of bleeding when taken with Actilyse.

This is not an exhaustive list of drug interactions. Always consult your healthcare professional for a complete list and to ensure the safe use of Actilyse.

Precautions

Before using Actilyse, consider the following precautions:

• Inform your healthcare professional about any allergies you have, especially to Alteplase or other similar medications.
• Inform your healthcare professional about any bleeding disorders or a history of bleeding problems.
• Inform your healthcare professional about any recent major surgeries, injuries, or trauma.
• Inform your healthcare professional about any current or previous use of blood thinners or antiplatelet medications.
• Inform your healthcare professional about any current or previous medical conditions, including liver or kidney disease, high blood pressure, or a history of stroke.

Storage

Actilyse should be stored at the recommended temperature as indicated on the packaging. Keep it out of the reach of children and pets. Do not use Actilyse if the packaging is damaged or if the medication has expired. Proper disposal methods should be followed as per local regulations.

Patient Tips

• Follow the prescribed dosage and administration instructions provided by your healthcare professional.
• Inform your healthcare professional about any medications, supplements, or herbal products you are taking before starting Actilyse.
• If you experience any signs of bleeding, such as unexplained bruising, nosebleeds, or prolonged bleeding, seek medical attention immediately.
• Inform your healthcare professional about any unusual or severe side effects you experience.
• Do not stop using Actilyse abruptly without consulting your healthcare professional.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Actilyse 10 mg powder and solvent for solution for injection and infusion (Health Professionals SmPC) Available at:
• Alteplase (Drugs.com) [Accessed 6 Jun. 2024] (online) Available at:
• Thrombolytic therapy (MedlinePlus) [Accessed 5 Jun. 2024] (online) Available at:
• Miller SE, Warach SJ. Evolving Thrombolytics: from Alteplase to Tenecteplase. Neurotherapeutics. 2023 Apr;20(3):664-678. doi: 10.1007/s13311-023-01391-3. Epub 2023 Jun 5. [Accessed 14 Jun. 2024] Available at: