Duovir-E Kit

Introduction

The Duovir-E contains the active ingredients Lamivudine, Zidovudine, and Efavirenz. It is commonly used in the treatment of HIV (human immunodeficiency virus) infection.

Uses

Duovir-E is prescribed to manage HIV infection in adults and pediatric patients weighing at least 40 kg (88 lbs).

Dosage and Administration

The typical dosage of Duovir-E is as follows:

• Lamivudine: 150 mg twice daily
• Zidovudine: 300 mg twice daily
• Efavirenz: 600 mg once daily, preferably at bedtime on an empty stomach

The medications are usually taken in combination as directed by a healthcare professional.

Mechanism of Action

Lamivudine, Zidovudine, and Efavirenz work together to inhibit the replication of HIV, thereby reducing the viral load in the body and slowing down the progression of the infection.

Side Effects

Common side effects of Duovir-E may include nausea, headache, dizziness, and fatigue. Serious side effects can include liver problems, blood disorders, and psychiatric symptoms. If any serious side effects occur, immediate medical attention should be sought.

Drug Interactions

Duovir-E may interact with other medications such as rifampicin, rifabutin, and other drugs that affect liver enzymes. It’s important to inform the healthcare provider about all current medications to avoid potential interactions.

Precautions

Patients should be cautious when using Duovir-E if they have a history of liver disease, psychiatric disorders, or certain blood disorders. It’s important to discuss all medical history and current medications with the healthcare provider before starting this treatment.

Storage

Duovir-E should be stored at room temperature, away from moisture and heat. It’s important to keep the medication out of reach of children.

Patient Tips

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Efavirenz 600 mg Film-Coated Tablets (Health Professionals SmPC) Available at:
• Efavirenz (Drugs.com) [Accessed 26 Jun. 2024] (online) Available at:
• efavirenz 400 mg-lamivudine 300 mg-tenofovir disoproxil mg tablet lamivudine (RX) [Accessed 13 Jun. 2024] (online) Available at:
• Efavirenz, Emtricitabine, and Tenofovir (MedlinePlus) [Accessed 19 Jun. 2024] (online) Available at:
• Costa B, Vale N. Efavirenz: History, Development and Future. Biomolecules. 2022 Dec 31;13(1):88. doi: 10.3390/biom13010088. [Accessed 10 Jun. 2024] Available at: