Isolazine Tablet

Introduction

Isolazine is a prescription medication that combines two active ingredients: Isosorbide Dinitrate and Hydralazine. Isosorbide Dinitrate belongs to a class of drugs called nitrates, while Hydralazine is a vasodilator. This medication is primarily used to treat certain heart conditions, such as angina and heart failure. It helps to relax and widen the blood vessels, improving blood flow and reducing the workload on the heart.

Uses

Isolazine is prescribed for the treatment of angina, a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart. It is also used to manage heart failure, a condition in which the heart is unable to pump blood effectively. This medication helps relieve symptoms such as shortness of breath, fatigue, and swelling in the legs.

Dosage and Administration

The dosage of Isolazine will vary depending on the individual’s condition and response to treatment. Follow the instructions provided by your healthcare professional. Generally, the recommended starting dose for adults is usually one tablet taken three times a day, with or without food. Your doctor may adjust the dose based on your specific needs. It is important not to crush or chew the tablets, as they should be swallowed whole with a glass of water.

Mechanism of Action

Isosorbide Dinitrate, one of the active ingredients in Isolazine, works by relaxing and widening the blood vessels, allowing for increased blood flow to the heart. This helps to relieve the symptoms of angina by reducing the workload on the heart and improving oxygen supply to the heart muscle. Hydralazine, the other active ingredient, also relaxes and widens the blood vessels, further improving blood flow and reducing the strain on the heart.

Side Effects

Common side effects include headaches, dizziness, flushing of the skin, and low blood pressure. These side effects are usually temporary and may subside as your body adjusts to the medication. However, if these side effects persist or worsen. Contact your healthcare professional.

In some cases, Isolazine may cause more serious side effects, such as a rapid or irregular heartbeat, chest pain, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

Drug Interactions

Isolazine may interact with other medications, including erectile dysfunction drugs like sildenafil (Viagra) or tadalafil (Cialis), as well as other medications that lower blood pressure. Inform your healthcare professional about all the medications you are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions.

Precautions

Before taking Isolazine, inform your healthcare professional if you have any allergies, especially to nitrates or hydralazine. Disclose any other medical conditions you have, such as liver or kidney problems. This medication may not be suitable for everyone, and your healthcare professional will determine if it is safe and appropriate for you.

Isolazine should not be taken if you are already taking medications that contain nitrates, as this can lead to a dangerous drop in blood pressure. Additionally, avoid alcohol while taking this medication, as it may increase the risk of side effects.

Storage

Isolazine should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Isolazine exactly as prescribed by your healthcare professional. Do not change the dosage or stop taking the medication without consulting your doctor.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• have regular check-ups with your healthcare professional to monitor your response to the medication and to check your blood pressure.
• Avoid sudden changes in posture, such as standing up quickly, as this may cause dizziness or lightheadedness.
• If you experience any new or worsening symptoms while taking Isolazine, such as increased chest pain or difficulty breathing, contact your healthcare professional immediately.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Isosorbide mononitrate and dinitrate: a medicine used to prevent angina symptoms and heart failure (NHS UK) [Accessed 9 Jun. 2024] (online) Available at:
• Apresoline Tablets 25 mg (Health Professionals SmPC) Available at:
• Hydralazine (Drugs.com) [Accessed 8 Jun. 2024] (online) Available at:
• hydralazine (RX) [Accessed 2 Jun. 2024] (online) Available at:
• Hydralazine (MedlinePlus) [Accessed 22 Jun. 2024] (online) Available at:
• Shahzad Qamar A, Zamir A, Khalid S, Ashraf W, Imran I, Hussain I, Rehman AU, Saeed H, Majeed A, Alqahtani F, Rasool MF. A review on the clinical pharmacokinetics of hydralazine. Expert Opin Drug Metab Toxicol. 2022 Oct;18(10):707-714. doi: 10.1080/17425255.2022.2129005. Epub 2022 Sep 27. [Accessed 4 Jun. 2024] Available at: