Keygraf 0.5 Capsule

Introduction

Keygraf is a prescription medication containing the active ingredient Tacrolimus. It is available in capsule form and is commonly used to treat certain immune disorders and prevent organ rejection in transplant patients.

Uses

Keygraf is primarily prescribed to prevent the rejection of transplanted organs, such as kidney, liver, or heart transplants. It is also used to treat certain immune disorders, such as atopic dermatitis (eczema) and psoriasis.

Dosage and Administration

The dosage of Keygraf may vary depending on the specific condition being treated and individual patient factors. Follow the instructions provided by your healthcare professional. Typically, the medication is taken orally, usually once or twice daily. Take the medication at the same time(s) each day for the best results. The capsules should be swallowed whole with a glass of water and should not be chewed or crushed.

Mechanism of Action

Keygraf works by suppressing the immune system, specifically by inhibiting the activity of certain immune cells called T-lymphocytes. This helps to prevent the immune system from attacking transplanted organs and reduces inflammation in immune disorders like atopic dermatitis and psoriasis.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, headache, tremor, and increased blood pressure. These side effects are usually mild and may improve over time. However, if any of these side effects persist or worsen, consult your healthcare professional.

In some cases, Keygraf may cause more serious side effects. These can include kidney problems, high blood sugar levels, high potassium levels, and an increased risk of infection. Seek medical attention immediately if you experience symptoms such as decreased urine output, persistent nausea or vomiting, unexplained weight gain, swelling, or signs of infection such as fever, chills, or persistent sore throat.

Drug Interactions

Keygraf may interact with certain medications, including but not limited to medications that affect the liver enzymes responsible for metabolizing Tacrolimus. Inform your healthcare professional about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and any herbal supplements.

Precautions

Before starting Keygraf, inform your healthcare professional about any known allergies to Tacrolimus or any other medications. Additionally, discuss your medical history, especially if you have any liver or kidney problems, diabetes, high blood pressure, or a weakened immune system.

Keygraf should not be used during pregnancy unless specifically recommended by your healthcare professional. Use effective contraception during treatment with this medication, as it may cause harm to an unborn baby.

Storage

Keygraf should be stored at room temperature, away from moisture and heat. Keep it in its original container and out of reach of children.

Patient Tips

• Take Keygraf exactly as prescribed by your healthcare professional.
• Do not stop taking the medication without consulting your healthcare professional, even if you feel better.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• Follow any additional instructions provided by your healthcare professional regarding diet, lifestyle changes, and monitoring of blood tests.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Vitiligo – Treatment (NHS UK) [Accessed 26 Jun. 2024] (online) Available at:
• Adoport 0.5 mg Hard Capsules (Health Professionals SmPC) Available at:
• Tacrolimus oral and injection (Drugs.com) [Accessed 3 Jun. 2024] (online) Available at:
• tacrolimus (RX) [Accessed 28 Jun. 2024] (online) Available at:
• Tacrolimus Injection (MedlinePlus) [Accessed 29 Jun. 2024] (online) Available at:
• Schutte-Nutgen K, Tholking G, Suwelack B, Reuter S. Tacrolimus – Pharmacokinetic Considerations for Clinicians. Curr Drug Metab. 2018;19(4):342-350. doi: 10.2174/1389200219666180101104159. [Accessed 6 Jun. 2024] Available at: