Naplex 333mg/145mg Tablet CR

Introduction

Naplex is a medication that contains the active ingredients Sodium Valproate and Valproic Acid. It is commonly prescribed under this brand name. Naplex is primarily used for the treatment of certain types of seizures, including generalized seizures, absence seizures, and complex partial seizures.

Uses

Naplex is prescribed to manage and control seizures in individuals with epilepsy. It can be used as a monotherapy or in combination with other antiepileptic medications. It helps to reduce the frequency and severity of seizures, allowing individuals to better manage their condition and improve their quality of life.

Dosage and Administration

The dosage of Naplex may vary depending on the individual’s age, weight, and the specific condition being treated. Follow the instructions provided by your healthcare professional. Typically, the medication is taken orally with or without food. It is usually prescribed to be taken two to three times daily. Do not crush or chew the tablet; swallow it whole with a glass of water.

Mechanism of Action

Naplex works by increasing the levels of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. GABA helps to reduce the excessive electrical activity that can lead to seizures. By increasing the levels of GABA, Naplex helps to stabilize the electrical activity in the brain, thereby reducing the occurrence of seizures.

Side Effects

Common side effects may include drowsiness, dizziness, nausea, vomiting, stomach pain, and changes in appetite. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult your healthcare professional.

In rare cases, Naplex may cause more serious side effects, such as liver problems, pancreatitis, and a decrease in the number of blood cells. If you experience symptoms such as yellowing of the skin or eyes, severe abdominal pain, or unusual bleeding or bruising, seek immediate medical attention.

Drug Interactions

Naplex may interact with certain medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare professional about all the medications you are taking, including prescription, over-the-counter, and herbal products. Some common drug interactions include interactions with medications that affect blood clotting, other antiepileptic medications, and medications that are metabolized by the liver.

Precautions

Before taking Naplex, inform your healthcare professional about any pre-existing medical conditions, including liver or kidney problems, blood disorders, or a history of pancreatitis. This medication may not be suitable for individuals with certain medical conditions or those who are pregnant or breastfeeding.

Naplex may also interact with alcohol and other substances that depress the central nervous system, leading to increased drowsiness and impaired coordination. Avoid alcohol consumption while taking this medication.

Storage

Naplex should be stored at room temperature, away from moisture and heat. Keep it out of the reach of children and pets. Do not use the medication if it has expired or if the packaging is damaged.

Patient Tips

• Take Naplex exactly as prescribed by your healthcare professional.
• Do not stop taking the medication suddenly without consulting your healthcare professional, as this may lead to an increase in seizures.
• If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• attend regular follow-up appointments with your healthcare professional to monitor the effectiveness of the medication and any potential side effects.
• If you experience any unusual symptoms or side effects while taking Naplex, contact your healthcare professional for further guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Sodium valproate: medicine to treat epilepsy and bipolar disorder (NHS UK) [Accessed 20 Jun. 2024] (online) Available at:
• Dyzantil 200mg prolonged-release tablets (Health Professionals SmPC) Available at:
• Depakote Capsules Dosage Guide (Drugs.com) [Accessed 15 Jun. 2024] (online) Available at:
• valproic acid (RX) [Accessed 21 Jun. 2024] (online) Available at:
• Valproic Acid (MedlinePlus) [Accessed 27 Jun. 2024] (online) Available at:
• Kupferberg HJ. Sodium valproate. Adv Neurol. 1980;27:643-54. [Accessed 30 Jun. 2024] Available at: