Orgamide 300mg Tablet ER

Introduction

Orgamide is a prescription medication that contains the active ingredient Acotiamide. It is available in tablet form and is commonly known by its brand name, Orgamide. This medication is primarily used for the treatment of certain gastrointestinal conditions.

Uses

Orgamide is prescribed for the management of functional dyspepsia, a condition characterized by persistent or recurrent pain or discomfort in the upper abdomen. It is specifically indicated for the relief of symptoms such as postprandial fullness, early satiety, upper abdominal bloating, and upper abdominal pain.

Dosage and Administration

The dosage of Orgamide may vary depending on the individual’s condition and response to treatment. Follow the instructions provided by your healthcare professional. Typically, the recommended dose is one tablet taken orally twice daily, preferably before meals. The tablet should be swallowed whole with a sufficient amount of water, without crushing or chewing.

Mechanism of Action

Acotiamide, the active ingredient in Orgamide, acts as a selective antagonist of the M1 and M2 subtypes of muscarinic acetylcholine receptors. By inhibiting the breakdown of acetylcholine, it enhances the release of acetylcholine in the gastrointestinal tract. This mechanism helps to improve the symptoms of functional dyspepsia by enhancing gastric motility and reducing gastric hypersensitivity.

Side Effects

Common side effects may include diarrhea, nausea, vomiting, abdominal pain, and headache. These side effects are usually mild and temporary. However, if you experience any persistent or severe side effects, seek medical attention.

Serious side effects are rare but may include allergic reactions, such as rash, itching, swelling, or difficulty breathing. If you experience any of these serious side effects, stop taking the medication immediately and seek immediate medical attention.

Drug Interactions

Orgamide may interact with certain medications, which can affect its effectiveness or increase the risk of side effects. Inform your healthcare professional about all the medications you are currently taking, including prescription medications, over-the-counter drugs, and any herbal supplements. Some medications that may interact with Orgamide include anticholinergic drugs, prokinetic agents, and certain antifungal medications. Your healthcare professional will be able to provide you with more specific information and guidance.

Precautions

Before starting Orgamide, inform your healthcare professional about any existing medical conditions you have, especially if you have a history of liver or kidney problems. Additionally, inform your healthcare professional about any allergies or sensitivities you may have.

Orgamide should not be used in individuals who are hypersensitive to Acotiamide or any of the other ingredients in the medication. Follow your healthcare professional’s instructions and not exceed the recommended dosage.

Storage

Orgamide should be stored at room temperature, away from direct sunlight and moisture. Keep the medication out of the reach of children and pets. Do not use the medication after the expiration date printed on the packaging.

Patient Tips

• Take Orgamide exactly as prescribed by your healthcare professional.
• If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not double the dose to make up for a missed dose.
• If you have any questions or concerns about the medication, consult your healthcare professional.
• Follow a healthy and balanced diet, and avoid triggers that may worsen your symptoms of functional dyspepsia.
• Keep a record of any side effects or changes in your symptoms and discuss them with your healthcare professional during follow-up appointments.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Shrestha DB, Budhathoki P, Subedi P, Khadka M, Karki P, Sedhai YR, Karki BR, Mir WAY. Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis. Cureus. 2021 Dec 20;13(12):e20532. doi: 10.7759/cureus.20532. eCollection 2021 Dec. [Accessed 29 Jun. 2024] Available at:
• Altan E, Masaoka T, Farré R, Tack J. Acotiamide, a novel gastroprokinetic for the treatment of patients with functional dyspepsia: postprandial distress syndrome. Expert Rev Gastroenterol Hepatol. 2012 Sep;6(5):533-44. doi: 10.1586/egh.12.34. [Accessed 26 Jun. 2024] Available at:
• Tack J, Janssen P. Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia. Expert Opin Investig Drugs. 2011 May;20(5):701-12. doi: 10.1517/13543784.2011.562890. Epub 2011 Mar 22. [Accessed 21 Jun. 2024] Available at:
• Sun Y, Song G, McCallum RW. Evaluation of acotiamide for the treatment of functional dyspepsia. Expert Opin Drug Metab Toxicol. 2014 Aug;10(8):1161-8. doi: 10.1517/17425255.2014.920320. Epub 2014 May 31. [Accessed 20 Jun. 2024] Available at: