Piclib Capsule

Introduction

Piclib is a prescription medication that contains the active ingredient Palbociclib. It is commonly known by its generic name and is available under the brand name Piclib. This medication is primarily used for the treatment of certain types of advanced breast cancer.

Uses

Piclib is prescribed for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. It is specifically indicated for use in combination with hormonal therapy in postmenopausal women or in men.

Dosage and Administration

The recommended dosage of Piclib is 125 mg taken orally once daily for 21 consecutive days, followed by 7 days off treatment. This 28-day cycle should be repeated as directed by your healthcare provider. The capsules should be swallowed whole with a glass of water, with or without food. It’s important to follow your healthcare provider’s instructions regarding the dosage and duration of treatment.

Mechanism of Action

Palbociclib, the active ingredient in Piclib, is a targeted therapy that belongs to a class of medications called cyclin-dependent kinase (CDK) 4/6 inhibitors. It works by inhibiting specific proteins in cancer cells that are involved in cell growth and division. By blocking these proteins, Palbociclib helps to slow down or stop the growth of cancer cells, thereby reducing the progression of advanced breast cancer.

Side Effects

Common side effects that have been reported with this medication include:

• Fatigue: Feeling tired or weak
• Nausea: Feeling sick to your stomach
• Hair loss: Thinning or loss of hair
• Diarrhea: Loose or watery stools
• Infections: Increased risk of infections

It’s important to note that not all patients will experience these side effects, and some may experience different side effects not listed here. Additionally, there may be more serious side effects associated with Piclib. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

Drug Interactions

Piclib may interact with other medications, including both prescription and over-the-counter drugs. Some common and potentially serious drug interactions include:

• Strong CYP3A inhibitors: Medications that inhibit the activity of the enzyme CYP3A, such as ketoconazole and clarithromycin, may increase the levels of Palbociclib in the body, leading to an increased risk of side effects.
• Strong CYP3A inducers: Medications that induce the activity of the enzyme CYP3A, such as rifampin and phenytoin, may decrease the levels of Palbociclib in the body, potentially reducing its effectiveness.

It’s important to inform your healthcare provider about all the medications you are currently taking, including herbal supplements and vitamins, to ensure safe and effective use of Piclib.

Precautions

Before starting treatment with Piclib, discuss any existing medical conditions or allergies with your healthcare provider. Additionally, inform your healthcare provider about any other medications you are taking, as well as any herbal supplements or vitamins, to avoid potential drug interactions.

Piclib is contraindicated in patients who are allergic to Palbociclib or any other ingredients in the medication. It should also be used with caution in patients with certain liver or kidney conditions.

Storage

Patient Tips

• Take Piclib as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your healthcare provider first.
• If you miss a dose, take it as soon as you remember, unless it is close to the time for your next scheduled dose. Do not take a double dose to make up for a missed dose.
• If you experience any new or worsening symptoms while taking Piclib, such as chest pain, shortness of breath, or unusual bleeding, contact your healthcare provider immediately.
• It’s important to attend all scheduled appointments with your healthcare provider for monitoring and follow-up.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• IBRANCE 100 mg film-coated tablets (Health Professionals SmPC) Available at:
• Palbociclib (Drugs.com) [Accessed 10 Jun. 2024] (online) Available at:
• palbociclib capsule (RX) [Accessed 2 Jun. 2024] (online) Available at:
• Palbociclib (MedlinePlus) [Accessed 9 Jun. 2024] (online) Available at:
• Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ. Palbociclib and Letrozole in Advanced Breast Cancer. N Engl J Med. 2016 Nov 17;375(20):1925-1936. doi: 10.1056/NEJMoa1607303. [Accessed 6 Jun. 2024] Available at: