Plermin Gel

Introduction

Plermin is a prescription medication that contains the active ingredient Becaplermin. It is available in gel form and is primarily used for the treatment of certain types of chronic skin ulcers, specifically diabetic foot ulcers.

Uses

Plermin is prescribed for the treatment of diabetic foot ulcers. These ulcers are commonly seen in individuals with diabetes and can be difficult to heal due to impaired blood flow and nerve damage. This medication promotes the growth of new tissue, helping to accelerate the healing process and reduce the risk of infection.

Dosage and Administration

Plermin should be applied topically to the affected area once daily. Before applying the gel, clean the ulcer site with a mild cleanser and pat it dry. A thin layer of the gel should then be applied directly to the ulcer, ensuring that the entire wound is covered. The treated area can be covered with a sterile dressing if necessary. Follow the dosage instructions provided by your healthcare professional and to continue using the medication for the prescribed duration.

Mechanism of Action

The active ingredient in Plermin, Becaplermin, is a recombinant human platelet-derived growth factor. It works by stimulating the growth of new cells and blood vessels, which are essential for the healing process. Becaplermin helps to promote the formation of granulation tissue, which fills the wound and aids in the formation of new skin.

Side Effects

Common side effects may include mild pain or discomfort at the application site, itching, and redness. These side effects are usually temporary and should improve with continued use. However, if you experience any severe or persistent side effects, such as severe pain, swelling, or signs of infection, seek medical attention.

Drug Interactions

Plermin is a topical medication and is not expected to have significant interactions with other medications. However, it is always important to inform your healthcare professional about all the medications, including over-the-counter drugs, supplements, and herbal products, that you are currently taking.

Precautions

Before using Plermin, inform your healthcare professional about any allergies you may have, especially to any ingredients in the gel. Additionally, let your healthcare professional know about any other medical conditions you may have, as well as any medications you are currently taking. Plermin should not be used on open wounds or surgical incisions, as it is specifically intended for the treatment of diabetic foot ulcers.

Storage

Plermin should be stored at room temperature, away from direct sunlight and heat sources. Keep the medication out of reach of children and pets. Do not freeze the gel.

Patient Tips

• Follow the dosage instructions provided by your healthcare professional and apply the gel as directed.
• Keep the ulcer site clean and dry before applying the gel.
• If you accidentally apply too much gel, gently remove the excess with a clean cloth or tissue.
• If you miss a dose, apply the gel as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• It may take several weeks of consistent use for the full benefits of Plermin to be seen. Be patient and continue using the medication as directed.
• If you have any questions or concerns about using Plermin, consult your healthcare professional for further guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Becaplermin topical (Drugs.com) [Accessed 14 Jun. 2024] (online) Available at:
• becaplermin gel (RX) [Accessed 4 Jun. 2024] (online) Available at:
• Becaplermin Topical (MedlinePlus) [Accessed 5 Jun. 2024] (online) Available at:
• Papanas N, Maltezos E. Becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Clin Interv Aging. 2008;3(2):233-40. doi: 10.2147/cia.s1106. [Accessed 27 Jun. 2024] Available at: