Synacthene 250mg Injection

Introduction

Synacthene is a prescription medication that contains the active ingredient Tetracosactide. It is available under the brand name Synacthene. This medication is primarily used to treat certain conditions of the adrenal glands.

Uses

Synacthene is prescribed to manage various adrenal gland disorders, including adrenal insufficiency. It can be used as a diagnostic tool to assess the function of the adrenal glands, as well as a treatment option for certain inflammatory conditions, such as rheumatoid arthritis and systemic lupus erythematosus.

Dosage and Administration

The dosage of Synacthene will vary depending on the specific condition being treated and the individual patient’s needs. It is typically administered by a healthcare professional in a clinical setting, such as a hospital or clinic. The injection is given intramuscularly or subcutaneously. The frequency and duration of treatment will be determined by the prescribing healthcare provider.

Mechanism of Action

Tetracosactide, the active ingredient in Synacthene, acts on the adrenal glands to stimulate the production and release of certain hormones, including cortisol. This helps to regulate various physiological processes in the body, such as the response to stress, inflammation, and immune function.

Side Effects

Common side effects may include injection site reactions, such as pain, redness, or swelling. Other common side effects may include headache, dizziness, and gastrointestinal disturbances.

Serious side effects are rare but can occur. These may include allergic reactions, difficulty breathing, chest pain, or swelling of the face, lips, tongue, or throat. If any of these serious side effects occur, seek immediate medical attention.

Drug Interactions

Synacthene may interact with other medications. Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Drug interactions can alter the effectiveness or increase the risk of side effects of both Synacthene and other medications.

Precautions

Before using Synacthene, inform your healthcare provider about any existing medical conditions you have, especially if you have a history of adrenal gland disorders, heart problems, high blood pressure, or diabetes. This medication may not be suitable for everyone, and your healthcare provider will assess the potential risks and benefits before prescribing it.

Avoid abrupt discontinuation of Synacthene, as this can lead to adrenal insufficiency. If you need to stop using this medication, your healthcare provider will provide guidance on how to gradually reduce the dosage.

Storage

Synacthene should be stored in a cool, dry place away from direct sunlight. It should be kept out of the reach of children and pets. Do not freeze or refrigerate the medication unless specifically instructed to do so. Always check the expiration date before using the medication, and discard any expired or unused vials properly.

Patient Tips

• Follow the dosage instructions provided by your healthcare provider and do not change the dosage without consulting them.
• If you experience any unexpected or concerning side effects, contact your healthcare provider immediately.
• Keep a record of your injections, including the date, time, and location of each injection site, to ensure proper rotation and avoid potential complications.
• Attend all scheduled appointments with your healthcare provider to monitor your progress and discuss any concerns or questions you may have.
• If you have any questions or concerns about Synacthene, speak to your healthcare provider or pharmacist for further information and guidance.

Please note that this description, as well as the other content on our website is for educational purposes only. We do not provide medical advice. For specific medical advices, diagnoses and treatment options you should consult with your doctor.

References

• Synacthen Ampoules 250 micrograms (Health Professionals SmPC) Available at:
• Cosacthen for Dogs (Canada) (Drugs.com) [Accessed 25 Jun. 2024] (online) Available at:
• ACTH stimulation test (MedlinePlus) [Accessed 17 Jun. 2024] (online) Available at:
• Osborne JP, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick A, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, O’Callaghan FK. Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. Eur J Paediatr Neurol. 2023 Jan;42:110-116. doi: 10.1016/j.ejpn.2022.12.007. Epub 2022 Dec 26. [Accessed 2 Jun. 2024] Available at: