Hydroxypropylmethylcellulose, Glycerin, Dextran 70

Hydroxypropylmethylcellulose, Glycerin, and Dextran 70 are three common pharmaceutical excipients that are commonly used as ingredients in oral and injectable medications to improve their efficacy and safety.
Hydroxypropylmethylcellulose (HPMC) is a water-soluble cellulose derivative commonly used as a thickening, gelling, and emulsifying agent in pharmaceutical formulations. It is also known to increase the stability of some medications by helping to prevent degradation in the gastrointestinal tract. HPMC is commonly found in over-the-counter (OTC) medications, such as capsules, tablets, and suppositories, due to its versatility and low toxicity.
Glycerin, a natural trihydric alcohol, is used in pharmaceutical formulations for various purposes, such as a humectant, solvent, and sweetening agent. It is particularly useful in the development of oral dosage forms like tablets, capsules, and suspensions due to its non-toxic, safe, and versatile nature. In addition, glycerin is widely used in injectable medications due to its ability to stabilize proteins, promote isotonicity, and facilitate the formation of amorphous solids.
Dextran 70 is a high molecular weight, highly branched polysaccharide composed of glucose monomers. It is often employed as a blood volume expander, plasma expander, and carrier for proteins, vitamins, and enzymes. Dextran 70 is known to improve the solubility and stability of proteins and is widely used in hospital settings to maintain appropriate blood volume in patients undergoing surgeries or experiencing acute blood loss.