Fosaprepitant

Fosaprepitant is an antiemetic medication, which means it helps prevent nausea and vomiting. It is a prodrug, which means it is converted into an active form, aprepitant, in the body. Aprepitant is a selective neurokinin-1 (NK1) receptor antagonist, and it works by blocking the action of substance P, a neurotransmitter that is involved in the nausea and vomiting response.
Fosaprepant is used in combination with other antiemetic drugs, such as dexamethasone and a 5-HT3 receptor antagonist, to prevent acute and delayed chemotherapy-induced nausea and vomiting. It is specifically used in highly emetogenic chemotherapy regimens, where the risk of severe nausea and vomiting is high. The medication is also approved for use in patients undergoing stem cell or bone marrow transplantation, where the risk of chemotherapy-induced nausea and vomiting is increased.
Fosaprepitant is usually administered as an intravenous injection or an oral capsule, and it should be taken exactly as prescribed by a healthcare professional. The medication should not be used in patients with a known hypersensitivity to aprepitant or any of its excipients, and it should be used with caution in patients with hepatic or renal impairment.