Ofloxacin, Ketorolac

Ofloxacin is a widely-used fluoroquinolone antibiotic medication. It effectively treats bacterial infections, including those affecting the urinary tract, lungs, skin, and bones. Ofloxacin targets a broad spectrum of bacteria and has potent antibacterial activity, particularly against Gram-negative pathogens like E. Coli, Enterobacter species, and Pseudomonas aeruginosa.
Ofloxacin is available as oral tablets, injectable solution, and in combination with other medications for improved efficacy. The standard oral dosage ranges from 200 to 400 mg twice a day, with adjustments depending on the severity and type of infection, and the patient’s age, weight, and renal function.
On the other hand, Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) with both analgesic and anti-inflammatory properties. It’s effective for relieving acute pain and inflammation associated with conditions such as dental surgery, musculoskeletal injuries, and minor surgery. Ketorolac inhibits the enzyme cyclooxygenase (COX), which decreases the production of prostaglandins—chemicals responsible for inflammation, pain, and fever.
The combination of Ofloxacin and Ketorolac can provide a dual-action therapy that alleviates pain, inflammation, and the symptoms of bacterial infection. This potent drug regimen is primarily used for acute pain management while treating infection sites with high vascularization or a rich lymphatic supply, like the post-operative setting or traumatic injury.
When using the Ofloxacin and Ketorolac combination, monitor renal function closely, especially for patients at risk for nephrotoxicity or those concurrently receiving nephrotoxic agents, like aminoglycoside antibiotics or other NSAIDs. It is important to prioritize patient safety and monitor the signs and symptoms of any adverse drug effects.