Mesna

Mesna, also known as Sodium 2-mercaptoacetate, is a medical substance used as an antidote to prevent and treat the toxic effects of certain chemotherapy drugs. Specifically, it is used in conjunction with Cyclophosphamide, an alkylating agent commonly used in cancer treatment.
Cyclophosphamide, when metabolized by the liver, forms a toxic metabolite called Acrolein. This metabolite can cause irritation and damage to the bladder, potentially leading to hemorrhagic cystitis, a condition characterized by bleeding and inflammation of the bladder.
Mesna is a thiol compound that acts as a sulfhydryl donor, binding with the toxic Acrolein in the urinary bladder to form a non-toxic, soluble compound that can be readily excreted. By neutralizing the Acrolein, Mesna helps to prevent and reduce the symptoms of hemorrhagic cystitis, ensuring a safer chemotherapy experience for patients.
Mesna is typically administered intravenously (IV) in a clinical setting, either concurrently or soon after the administration of Cyclophosphamide. The dosage of Mesna is adjusted based on the patient’s body weight and the dose of Cyclophosphamide received. It is important to monitor the patient’s renal function and urine output during Mesna administration to ensure its safe and effective use.