Ankylosing spondylitis

Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis condition that primarily affects the spine. It can cause severe pain, stiffness, and limited mobility, primarily affecting the lower back and sacroiliac joints. Over time, this condition may lead to spinal fusion, resulting in reduced mobility and a forward-leaning posture.
The medications available to help manage ankylosing spondylitis aim to alleviate pain, reduce inflammation, and prevent joint damage. Some commonly used categories of medications for AS treatment include:

Nonsteroidal anti-inflammatory drugs (NSAIDs): These medications help to relieve pain and reduce inflammation by blocking the production of prostaglandins, which are responsible for initiating inflammatory responses. Commonly prescribed NSAIDs include ibuprofen, naproxen, and diclofenac.
Disease-modifying antirheumatic drugs (DMARDs): DMARDs help slow the progression of joint damage in patients with ankylosing spondylitis. Examples include sulfasalazine and methotrexate.
Tumor necrosis factor (TNF) inhibitors: TNF inhibitors are a class of biological agents that target specific proteins responsible for inflammation in the joints. Examples of TNF inhibitors used to treat AS are etanercept, infliximab, adalimumab, and certolizumab pegol.
Interleukin-17 (IL-17) inhibitors: These medications work by inhibiting a specific protein (interleukin-17) involved in inflammation. An example of this class is secukinumab.

It’s crucial to consult with a healthcare professional before beginning any new treatment to ensure that the appropriate medication is selected based on an individual’s specific needs, medical history, and potential side effects. Always follow your healthcare provider’s guidance regarding medication dosage, frequency, and any additional instructions.